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目的进一步探索肺结核化疗的合理性。方法对147例初治涂阳的肺结核病人采用强化期链霉素(S)、雷米封(H)、利福平(R)、吡嗪酰胺(Z)、治疗至少2个月。对治疗2个月以上痰涂片未转阴者继续强化治疗直至痰菌转阴。以痰菌转阴为界,用HR巩固治疗3个月(巩固治疗疗程含2个月内转阴后的强化期)。结果满疗程痰菌阴转率100%,平均化疗期4.72个月。经2年随访,细菌学复发率为1.42%。结论不固定化疗期4.72个月不仅可以取得与2SHRZ/4HR相同的近期痰菌阴转率,还可以使治疗6个月痰未转阴的初治病例得到成功治疗
Objective To explore the rationality of pulmonary tuberculosis chemotherapy. Methods Streptomycin (S), Remy seal (H), Rifampicin (R) and Pyrazinamide (Z) were used to treat 147 newly smear-positive pulmonary tuberculosis patients for at least 2 months. On the treatment of sputum smear more than 2 months to continue treatment until sputum negative. To sputum negative for the community, with HR consolidation treatment for 3 months (consolidate the course of treatment within 2 months with negative after the strengthening period). The results of full course sputum negative conversion rate of 100%, the average chemotherapy period of 4.72 months. After 2 years follow-up, bacteriological relapse rate was 1.42%. Conclusions The 4.72 months of unfixed chemotherapy period can not only achieve the same short-term sputum negative conversion rate as 2SHRZ / 4HR, but also make the successful treatment of untreated untreated sputum in 6 months