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目的进一步探索肺结核化疗的合理性。方法对１４７例初治涂阳的肺结核病人采用强化期链霉素（Ｓ）、雷米封（Ｈ）、利福平（Ｒ）、吡嗪酰胺（Ｚ）、治疗至少２个月。对治疗２个月以上痰涂片未转阴者继续强化治疗直至痰菌转阴。以痰菌转阴为界，用ＨＲ巩固治疗３个月（巩固治疗疗程含２个月内转阴后的强化期）。结果满疗程痰菌阴转率１００％，平均化疗期４．７２个月。经２年随访，细菌学复发率为１．４２％。结论不固定化疗期４．７２个月不仅可以取得与２ＳＨＲＺ／４ＨＲ相同的近期痰菌阴转率，还可以使治疗６个月痰未转阴的初治病例得到成功治疗
Objective To explore the rationality of pulmonary tuberculosis chemotherapy. Methods Streptomycin (S), Remy seal (H), Rifampicin (R) and Pyrazinamide (Z) were used to treat 147 newly smear-positive pulmonary tuberculosis patients for at least 2 months. On the treatment of sputum smear more than 2 months to continue treatment until sputum negative. To sputum negative for the community, with HR consolidation treatment for 3 months (consolidate the course of treatment within 2 months with negative after the strengthening period). The results of full course sputum negative conversion rate of 100%, the average chemotherapy period of 4.72 months. After 2 years follow-up, bacteriological relapse rate was 1.42%. Conclusions The 4.72 months of unfixed chemotherapy period can not only achieve the same short-term sputum negative conversion rate as 2SHRZ / 4HR, but also make the successful treatment of untreated untreated sputum in 6 months