论文部分内容阅读
用病毒治疗肿瘤是一种日益引起人们重视的肿瘤治疗手段 [1 ] 。早在 2 0世纪5 0年代 ,人们就开始利用腺病毒 (aden-ovirus,Ad)的细胞毒性进行治疗宫颈癌的试验。自杀基因疗法的原理是将“自杀”基因转移入宿主细胞的基因组中 ,这种基因编码的酶能使非活性的前药转化为细胞毒性?
Treating the tumor with the virus is an increasingly important approach to cancer treatment [1]. As early as the 1950s, people started to use the cytotoxicity of adenovirus (adenovirus) to treat cervical cancer. The principle of suicide gene therapy is to transfer the “suicide” gene into the genome of the host cell, and how does the enzyme encoded by this gene turn inactive prodrugs into cytotoxicity?