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在慢性稳定型心绞痛患者的治疗中,β-肾上腺能受体阻滞剂可减少心绞痛的发作频数和严重程度,减少硝酸甘油酯的用量,改善ST段的压低,以及增加运动的耐受性。对有心力衰竭、心脏传导阻滞,严重的二尖瓣和主动脉瓣病变、周围血管病或阻塞性气道疾病等患者β-阻滞剂宜慎用。用药后不能立即停药,因为突然停药可能使某些病人心绞痛的发作频率和疼痛程度反跳性地增剧。对阻塞性气道病患者,可在严密的监护下,试用心脏选择性β-阻滞剂(如Metoprolol和Atenolo1)。对心绞痛和左室功能不全患者,最好合用β-阻滞剂与洋地黄。然而,对某些重度稳定型心绞痛患者不能用β-阻滞剂(无效或因合并症忌用)。
In the treatment of patients with chronic stable angina, beta-adrenergic receptor blockers reduce the frequency and severity of angina attacks, reduce nitroglycerin use, improve ST-segment depression, and increase exercise tolerance. Beta-blockers should be used with caution in patients with heart failure, heart block, severe mitral and aortic valve disease, peripheral vascular disease, or obstructive airway disease. Can not be discontinued immediately after treatment because sudden withdrawal may increase the frequency and intensity of angina attacks rebound in some patients. For patients with obstructive airways disease, heart-selective β-blockers (such as Metoprolol and Atenolol) may be tested under tight surveillance. For angina and left ventricular dysfunction in patients with beta-blockers and digitalis is best combined. However, β-blockers can not be used in patients with severe stable angina (ineffective or due to complications).