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目的探讨子宫内膜癌(EC)组织中CD44拼构变异体6(CD44v6)、基质金属蛋白酶-2(MMP-2)及其抑制剂-2(TIMP-2)的表达,分析其与EC浸润、转移的关系。方法用免疫组化技术对73例EC组织和27例正常增生期子宫内膜组织中MMP-2、TIMP-2及CD44v6的表达情况检测分析。结果 MMP-2、TIMP-2及CD44v6在EC中的阳性表达均显著高于对照组(P<0.05)。子宫内膜癌中:MMP-2和TIMP-2的表达仅与肌层浸润有关(P<0.05);CD44v6与肌层浸润深度有关(P<0.05),CD44v6的阳性表达率随淋巴结转移和病理分级增高有下降的趋势,但无统计学意义(P>0.05)。MMP-2和TIMP-2及MMP-2和CD44v6在EC组织中的表达呈正相关(P<0.05)。结论 MMP-2、TIMP-2及CD44v6高表达的EC患者更易发生浸润、转移。联合检测MMP-2、TIMP-2及CD44v6的表达,可能对预测EC的转移和预后评估有重要意义。
Objective To investigate the expression of CD44v6, MMP-2 and TIMP-2 in endometrial carcinoma (EC) , The transfer of the relationship. Methods The expression of MMP-2, TIMP-2 and CD44v6 in 73 cases of EC and 27 cases of normal proliferative endometrium were detected by immunohistochemistry. Results The positive expression of MMP-2, TIMP-2 and CD44v6 in EC was significantly higher than that in the control group (P <0.05). In endometrial carcinoma, the expression of MMP-2 and TIMP-2 was only associated with myometrial invasion (P <0.05); CD44v6 was associated with the depth of myometrial invasion (P <0.05); the positive rate of CD44v6 was correlated with lymph node metastasis and pathological changes Grading increased with a downward trend, but no statistical significance (P> 0.05). The expressions of MMP-2, TIMP-2, MMP-2 and CD44v6 in EC tissues were positively correlated (P <0.05). Conclusion The patients with high expression of MMP-2, TIMP-2 and CD44v6 are more likely to infiltrate and metastasize. Joint detection of MMP-2, TIMP-2 and CD44v6 expression may predict EC metastasis and prognosis of great significance.