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目的：比较占替诺烟酸盐治疗脑梗死的疗效。方法：１００例脑梗死病人，其中５０例（男性２８例，女性２２例；年龄６２±ｓ８ａ）采用占替诺烟酸盐３００～９００ｍｇ加入０．００４％倍他司汀５００ｍＬ，静脉滴注，ｑｄ，１０ｄ为一个疗程，隔２～３ｄ后再用第２个疗程。另５０例为对照组（男性３０例，女性２０例；年龄６３±７ａ）采用川芎嗪１２０ｍｇ加入０．００４％倍他司汀５００ｍＬ，静脉滴注，ｑｄ，方法与疗程同前。结果：占替诺烟酸盐组总有效率８８％，显效率７２％。川芎嗪组总有效率７０％，显效率３２％，经Ｒｉｄｉｔ分析：Ｐ＜０．０５。同时还发现占替诺烟酸盐对血脂、血液流变学均有显著改善（Ｐ＜０．０１）。该药不良反应较少。结论：占替诺烟酸盐是治疗脑梗死的良好药物。
OBJECTIVE: To compare the efficacy of zolmitronic acid in the treatment of cerebral infarction. Methods: 100 cases of cerebral infarction patients, of which 50 cases (28 males and 22 females; age 62 ± s8a) with centynronate 300 ~ 900mg added 0.004% betahistine 500mL, intravenous drip, qd, 10d for a course of treatment, every 2 ~ 3d after the second course of treatment. The other 50 cases as the control group (30 males and 20 females; age 63 ± 7a) with ligustrazine 120mg 0.004% Betamethasone 500mL, intravenous drip, qd, with the same treatment. Results: The total effective rate in the nicotinamide group was 88%, and the effective rate was 72%. Ligustrazine group, the total effective rate was 70%, markedly effective rate of 32%, Ridit analysis: P <0.05. At the same time, it was also found that zanutonic acid significantly improved blood lipids and hemorheology (P <0.01). The drug adverse reactions less. CONCLUSION: ZENZINOL niacin is a good drug for the treatment of cerebral infarction.