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抗核抗体,又称抗核酸抗原抗体,是一组将自身真核细胞的各种成分脱氧核糖核蛋白(DNP)、DNA,可提取的核抗原(ENA)和RNA等作为靶抗原的自身抗体的总称,主要存在于血清中,也可存在于胸水、关节滑液和尿液中。抗核抗体谱包括抗核抗体(ANA)、抗DNA抗体、抗核内可溶性抗原抗体(ENA)。ENA又包括抗史密斯抗体(Sm)、抗核糖核蛋白体(RNP)抗体、抗干燥综合征A(SSA/Ro)抗体、抗干燥综合征B(SSB/La)抗体、抗硬皮病-70(Scl-70)抗体。临床意义为:ANA为一系列抗细胞核抗原的自身抗体的总称。一般应用免疫荧光的方法检测。
Anti-nuclear antibody, also known as anti-nucleic acid antigen antibody, is a set of autoantibodies that target various components of their own eukaryotic cells, such as deoxyribonucleoprotein (DNP), DNA, extractable nuclear antigen (ENA) The general term, mainly in serum, but also in pleural effusion, synovial fluid and urine. Antinuclear antibody profiles include anti-nuclear antibody (ANA), anti-DNA antibody, anti-nuclear soluble antigen antibody (ENA). ENA, in turn, includes antibodies against Sm, RNP, SSA / Ro, SSB / La, anti-scleroderma-70 (Scl-70) antibody. Clinical Significance: ANA is a series of autoantibodies against the cell nuclear antigen in general. General application of immunofluorescence detection method.