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选择22例脑梗塞患者,口服穿心莲黄酮糖依片1个月,观察治疗前后脑梗塞患者的临床疗效和血栓性指标的变化。结果表明 1疗效显著者5例占23%,有效14例,占64%,总有效率87%;2用药后血浆TxB2、Gmp-140、PAI/TPA水平均明显降低(P均<0.05),血浆ET有一定程度降低,TPA有一定程度升高但均不显著(P均>0.05),血浆6KPGF1α、PAI水平无变化。3用药前后患者肝、肾功能、三大常规均无变化。揭示:穿心莲黄酮具有较强的抗血栓、促进纤溶作用,并可能有一定的舒张血管作用,对脑梗塞具有良好的治疗作用。
Twenty-two patients with cerebral infarction were selected for oral administration of andrographolide flavonoids for one month. The changes of clinical efficacy and thrombosis indexes in patients with cerebral infarction before and after treatment were observed. The results showed that 1 significant effect in 5 cases accounted for 23%, effective in 14 cases, accounting for 64%, the total effective rate was 87%; 2 after administration of plasma TxB2, GMP-140, PAI / TPA levels were significantly lower (P all <0.05) Plasma ET decreased to a certain extent, TPA increased to some extent but not significantly (all P> 0.05), plasma 6KPGF1α, PAI levels did not change. 3 before and after treatment of patients with liver and kidney function, no change in the three major conventional. Reveal: Andrographis flavone has a strong anti-thrombosis, promote fibrinolysis, and may have some vasodilatation, cerebral infarction has a good therapeutic effect.