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A semi-empirical turbulence enhancement model accounting for the particle-wake effect was incorporated into the second-order moment two-phase turbulence model and employed to simulate gas-particle flows in a swirling sudden-expansion chamber. The simulated results for two-phases mean velocities and fluctuation velocities coincide well with the experiment ones, which demonstrates that this model, in comparison with the turbulence model not accounting for the wake effect, leads to higher calculating accuracy.