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16例健康志愿者参加了随机、双盲、交叉试验。在进餐3～4小时后,8例受试者在30秒内静脉注射安慰剂或西沙必利10mg;另8例口服安慰剂或西沙必利5、10和20 mg。每次给药间隔1周。每次给药前后定时测定有关参数。结果:静注西沙必利10mg,15分钟后静息食管下段括约肌(LES)压力较治疗前增加3 mmHg(P<0.05),45分钟后增加最明显(6 mmHg);口服西沙必利20 mg,45分钟后静息LES压力较治疗前增加5 mmHg(P<0.05),75分钟后增加最明显(8 mmHg),口服西沙必利5和10
Sixteen healthy volunteers participated in a randomized, double-blind, crossover trial. After 3 to 4 hours of mealtime, 8 subjects received either a placebo or cisapride 10 mg intravenously within 30 seconds; and the other 8 placebo or cisapride 5, 10 and 20 mg orally. Each administration interval of 1 week. Before and after each dose determination of the relevant parameters. Results: After sisapride 10 mg intravenous infusion, the pressure of resting lower esophageal sphincter (LES) increased 3 mmHg (P <0.05) 15 minutes later, and the most obvious increase (6 mmHg) 45 minutes later. Oral cisapride 20 mg After 45 minutes, the resting LES pressure increased by 5 mmHg (P <0.05) before treatment, and the most significant increase (8 mmHg) after 75 minutes. Cisapride 5 and 10