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The present study observed the effects of MCI-186 on the intracellular calcium ion concentra-tion ([Ca2+]i) and membrane fluidity of hippocampal neurons in Alzheimer’s disease (AD) model rats to validate the neuroprotective effects of MCI-186.Compared with normal and sham-operated rats,the escape latency was obviously prolonged,spanning platform times were obviously reduced,[Ca2+]i was increased,and microviscosity η value was increased in AD rats.MCI-186 at 0.5 mg/mL and 0.2 mg/mL obviously shortened escape latency,increased spanning platform times and decreased [Ca2+]i and microviscosity η values in AD rats at 7 and 17 days after induction of the model.The differences in the above-mentioned indices between normal and MCI-186-treated rats were statistically significant.MCI-186 at 0.2 mg/mL yielded better curative effects than 0.5 mg/mL MCI-186.These findings suggest that MCI-186 improves learning and memory abilities in AD rats by decreasing [Ca2+]i and increasing membrane fluidity of hippocampal neurons.
The present study observed the effects of MCI-186 on the intracellular calcium ion concentra tion ([Ca2 +] i) and membrane fluidity of hippocampal neurons in Alzheimer’s disease (AD) model rats to validate the neuroprotective effects of MCI- 186. Compared with Normal and sham-operated rats, the escape latency was obviously prolonged, spanning the platform times were significantly reduced, [Ca2 +] i was increased, and microviscosity η value was increased in AD rats. MCI-186 at 0.5 mg / mL and 0.2 mg / mL obviously shortened escape latency, increased spanning platform times and decreased [Ca2 +] i and microviscosity values in AD rats at 7 and 17 days after induction of the model. differences in the above-mentioned indices between normal and MCI-186-treated mice are measured significantly.MCI-186 at 0.2 mg / mL yielded better curative effects than 0.5 mg / mL MCI-186. These findings suggest that MCI-186 improves learning and memory abilities in AD rats by decreasing [Ca 2+] i and increasing membranes fluidity o f hippocampal neurons.