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目的探讨螺旋藻精片对小鼠免疫功能的调节作用。方法以小鼠为实验对象,分别以333.4、666.7、1333.4mg/kg.bw3个剂量组的螺旋藻给予小鼠灌胃30～35d后,测定脾淋巴细胞转化、迟发型变态反应、抗体生成细胞数量、血清溶血素水平、碳廓清原、腹腔巨噬细胞吞噬鸡红细胞能力和NK细胞活性等七项免疫指标。结果各剂量组的各项检测结果与阴性对照组比,均能刺激小鼠脾淋巴细胞增值、转化作用;促进小鼠迟发型变态反应作用;提高小鼠抗体生成细胞数和血清溶血素水平,增强小鼠的单核-腹腔巨噬细胞吞噬和碳廓清能力,但对小鼠NK细胞活性功能无明显作用。结论螺旋藻具有增强小鼠免疫功能作用。
Objective To investigate the regulatory effect of Spirulina Tablet on immune function in mice. Methods Mice were used as experimental subjects. Spirulina was administered to mice at 333.4, 666.7, and 1333.4 mg/kg.bw gavage for 30 to 35 days. Splenic lymphocyte transformation, delayed hypersensitivity, and antibody-producing cells were measured. Quantitative, serum hemolysin levels, carbon clearance, peritoneal macrophage phagocytization of chicken erythrocytes and NK cell activity were seven immune indicators. Results Compared with the negative control group, the detection results of each dose group were able to stimulate the increase and conversion of spleen lymphocytes in mice, promote the delayed allergic reaction in mice, and increase the number of antibody-producing cells and serum hemolysin in mice. The phagocytosis and carbon clearance ability of mononuclear-peritoneal macrophages in mice was enhanced, but there was no significant effect on the activity of mouse NK cells. Conclusion Spirulina can enhance the immune function of mice.