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正己烷属饱和脂肪烃类,广泛应用于黏胶、电子器件清洗、印刷、干洗、家具、运动器材及制鞋等行业中,主要通过呼吸道和胃肠道等途径进入人体,分布于脂肪含量高的组织,对中枢神经系统有抑制作用,长期接触可致多发性周围神经病变。2,5-己二酮(2,5-Hexadione,2,5-HD)是正己烷的主要代谢产物,属γ-二酮类化合物,目前被认为是正己烷毒性的关键物质。近年来正己烷毒性研究主要集中在神经毒理学
Hexane saturated aliphatic hydrocarbons, widely used in viscose, electronic device cleaning, printing, dry cleaning, furniture, sports equipment and footwear industries, mainly through the respiratory tract and gastrointestinal tract into the body, located in the high fat content Of the organization, inhibit the central nervous system, long-term exposure can cause multiple peripheral neuropathy. 2,5-Hexadione (2,5-HD), the main metabolite of n-hexane, belongs to the class of γ-diketones and is currently considered to be a key substance in n-hexane toxicity. In recent years, n-hexane toxicity studies have focused on neurotoxicology