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尿激酶型纤溶酶原激活物(u-PA)的过度表达与肿瘤细胞的侵袭和转移密切相关。胃癌是最常见的消化道肿瘤,而u-PA在胃癌中高表达,研究u-PA及其作用,系统的产生调节机制及生物学功能将有助于了解胃癌的浸润转移以及u-PA系统在胃癌临床治疗方面的意义。
Overexpression of urokinase-type plasminogen activator (u-PA) is closely related to tumor cell invasion and metastasis. Gastric cancer is the most common gastrointestinal cancer, while u-PA is highly expressed in gastric cancer. The study of u-PA and its role in the regulation of the mechanism and biological function of the system will help to understand the invasion and metastasis of gastric cancer and u-PA system in Significance of clinical treatment of gastric cancer.