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目的探讨医源性失血与早产儿贫血的发生以及需要输血的关系。方法本院儿科2005年1月至2006年12月生后24h收入新生儿病房的早产儿165例为研究对象,按2周内采血量的不同,把研究对象分为3组:A组:<7.5ml/kg;B组:7.5~15ml/kg;C组:≥15ml/kg,进行采血量与早产儿贫血的相关性分析;按4周内采血量的不同,把研究对象分3组:Ⅰ组:<7.5ml/kg;Ⅱ组:7.5~15ml/kg;Ⅲ组:≥15ml/kg,进行采血量与早产儿输血的相关性分析。结果165例早产儿中发生贫血63例,占总例数的38.1%,A组贫血比例为18.4%(16/87),B组为47.2%(25/53),C组为88.0%(22/25);输血7例,Ⅰ组输血比例为0%(0/78),Ⅱ组为4.1%(2/49),Ⅲ组为13.2%(5/38)。2周采血量与贫血的发生呈显著正相关(rs=0.49,P<0.001),4周采血量与输血呈显著正相关(rs=0.244,P=0.002)。结论医源性失血量越大,早产儿发生贫血的可能性越大,输血的可能性也越大。
Objective To explore the relationship between iatrogenic blood loss and anemia in premature infants and the need for blood transfusion. Methods A total of 165 preterm infants admitted to the neonatal ward from January 2005 to December 2006 were enrolled in this study. Subjects were divided into three groups according to the amount of blood taken within two weeks: Group A: 7.5ml / kg in group B, 7.5-15ml / kg in group B, 15ml / kg in group C, the correlation between the amount of blood taken and anemia in preterm infants was analyzed. According to the amount of blood taken in 4 weeks, the subjects were divided into 3 groups: Group Ⅰ: <7.5ml / kg; Group Ⅱ: 7.5-15ml / kg; Group Ⅲ: ≥15ml / kg, the correlation between the amount of blood taken and the blood transfusion in preterm infants was analyzed. Results There were 63 anemic cases in 165 preterm infants, accounting for 38.1% of the total cases. The anemia in group A was 18.4% (16/87), in group B 47.2% (25/53) and in group C 88.0% (22 / 25); blood transfusion in 7 cases, the rate of blood transfusion in group I was 0% (0/78), that in group II was 4.1% (2/49) and in group III was 13.2% (5/38). There was a significant positive correlation between the amount of blood taken and the occurrence of anemia in two weeks (rs = 0.49, P <0.001). There was a significant positive correlation between blood volume and blood transfusion in four weeks (rs = 0.244, P = 0.002). Conclusion The larger the amount of iatrogenic blood loss, the greater the possibility of anemia in premature children and the greater the possibility of blood transfusion.