γ-氨基丁酸(GABA)是已知的中枢神经抑制性递质,新近已证明在周围组织中存在GABA受体,这也包括肺组织。在动物试验中已显示GABA及其激动剂氯苯氨丁酸可抑制支气管对各种收缩剂的高反应性。这一结果提示,氯苯氨丁酸也有可能抑制人类的气道高反应性。近来发现颈髓损伤四肢瘫痪的患者总是出现对乙酰胆碱的气道高反应性,原因是气道交感神经支配的中断以及颈髓横断后胆碱能神经张力的绝对增 Gamma-aminobutyric acid (GABA), a known central nervous inhibitory neurotransmitter, has recently been demonstrated to have GABA receptors in surrounding tissues, which also include lung tissue. It has been shown in animal studies that GABA and its agonist chlorbenzidine inhibit bronchial hyperresponsiveness to various contractile agents. This result suggests that chlorbenzuron may also inhibit human airway hyperresponsiveness. Recently, it has been found that patients with paralyzed cervical spinal cord injury always have airway hyperresponsiveness to acetylcholine because of the absolute increase in the interruption of airway sympathetic innervation and the cholinergic tone after spinal cord transection