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目的 了解非胰岛素依赖型糖尿病 (NIDDM)合并胆石症患者血中胰岛素水平和脂质代谢方面的改变。方法 分别采集 15 9例我院近 3年来内分泌科门诊及住院NIDDM病人空腹和餐后 2h血样 ,检测血清中血糖、血脂、载脂蛋白A1和B、胰岛素含量 ,观察比较 2型糖尿病合并胆石症 (10 3例 )与不合并胆石症患者 (5 6例 )血清中相关指标的差异。结果 NIDDM合并胆石症患者以女性居多 ,既往高峰体质指数和血液中甘油三酯、胰岛素水平和胰岛素敏感指数、载脂蛋白A1和B、明显高于无胆石组 ;而年龄、病程、血糖、高密度脂蛋白与低密度脂蛋白等无显著性差异。结论 NIDDM合并胆石症可能与肥胖、高胰岛素血症和胰岛素抵抗以及脂类代谢紊乱有关。
Objective To investigate the changes of blood insulin levels and lipid metabolism in non-insulin dependent diabetes mellitus (NIDDM) patients with cholelithiasis. Methods Fifty-nine cases of endocrinology clinic and inpatient NIDDM patients in our hospital for 3 years were collected for fasting and postprandial blood samples for 2h. Serum levels of blood glucose, lipids, apolipoproteins A1 and B, and insulin were measured respectively. The incidence of type 2 diabetes complicated with cholelithiasis (103 cases) and non-patients with cholelithiasis (56 cases). Results The majority of NIDDM patients with cholelithiasis were female, the former peak body mass index and blood triglyceride, insulin and insulin sensitivity index, apolipoprotein A1 and B were significantly higher than those without gallstone group; while age, duration, blood glucose, high There was no significant difference between LDL and LDL. Conclusion NIDDM with cholelithiasis may be related to obesity, hyperinsulinemia and insulin resistance, and disorders of lipid metabolism.