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血管紧张素Ⅱ1型受体拮抗剂从多方面阻滞血管紧张素Ⅱ的功能,来抑制动脉粥样硬化的形成和发展:降低核因子κB活性而抑制趋化因子及粘附分子的释放,对抗炎症反应;降低细胞内总氧化能力,减少自由基生成,减弱低密度脂蛋白氧化,抑制巨噬细胞吞噬氧化型低密度脂蛋白的能力,从而减少泡沫细胞形成;增加内皮源性血管舒张因子水平,保护血管内皮;抑制血管平滑肌细胞迁移和增殖;降低血小板黏附、聚集活性,抑制血栓形成;减少动脉斑块内胆固醇酯含量,减少巨噬细胞浸润、抑制基质金属蛋白酶1的表达,增加斑块稳定性。
Angiotensin II type 1 receptor antagonists block the function of angiotensin II in many aspects to inhibit the formation and development of atherosclerosis by reducing the activity of nuclear factor kappa B and inhibiting the release of chemokines and adhesion molecules Inflammatory reaction; reduce the total intracellular oxidation capacity, reduce free radical generation, weakening the oxidation of low density lipoprotein, macrophage inhibition of phagocytosis of oxidized low density lipoprotein, thereby reducing the formation of foam cells; increase the level of endothelium-derived vasodilator , Protect vascular endothelium; inhibit vascular smooth muscle cell migration and proliferation; reduce platelet adhesion, aggregation activity, inhibit thrombosis; reduce arterial plaque cholesterol ester content, reduce macrophage infiltration, inhibit the expression of matrix metalloproteinase 1 and increase plaque stability.