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长期大量服用呋喃类药物所引起的神经系统损害,已为人所知;但小剂量服用痢特灵即引起周围神经炎,却报道甚少,现将我们遇到的3例结合文献加以讨论。临床资料本组病例男性1例,女性2例。年龄32～46岁。发病前半月至1月均有“肠炎”病史,服用痢特灵量分别为6片、4片和30片,约服药后5至20天左右,逐渐出现不同程度的末梢型对称性肢体感觉和/或运动障碍,表现为四肢麻木、无力,肌痛。呈手套及袜子状感觉减退,肌力Ⅳ～Ⅳ~+级,肌张力降低,腱反射减弱。均查肌电图提示:神经源性异常。体感诱发电位均正常。均行腰穿检查,脑脊液细胞蛋白正常。血清K~+均在正常范
Long-term large doses of furan drugs caused by nervous system damage is already known; but taking small doses of furazolidone that is caused by peripheral neuritis, but little reported, now we encounter 3 cases of combined literature to be discussed. Clinical data of 1 case of male patients, 2 females. Age 32 ~ 46 years old. The first half of the disease to January have a history of “enteritis”, taking doses of furazolidone were 6, 4 and 30, about 5 to 20 days after taking the medication, and gradually varying degrees of peripheral symmetrical limb sensory and / Or dyskinesia, manifested as numbness, weakness, myalgia. Gloves and socks were feeling diminished, muscle strength Ⅳ ~ Ⅳ ~ + level, decreased muscle tone, decreased tendon reflexes. Check EMG Tip: neurogenic abnormalities. Somatosensory evoked potentials were normal. Were performed lumbar puncture, cerebrospinal fluid cell protein normal. Serum K ~ + are in the normal range