【摘 要】
：
Quassinoids,a class of highly oxygenated triterpenes,have been isolated as bitter principles from the plants of Simaroubaceae family.Five new quassinoids,chouch
【机 构】
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Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development,Liaoni
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Quassinoids,a class of highly oxygenated triterpenes,have been isolated as bitter principles from the plants of Simaroubaceae family.Five new quassinoids,chouchunlactone A—E (1-5),and two known ones were identified from the root barks of Ailanthus altissima Swingle (Simaroubaceae).The chemical structures of the new compounds were deduced by spectroscopic data analyses,NMR calcu-lations and DP4+ probability analysis.The absolute configurations were defined by comparison of their experimental and calculated electronic circular dichroism (ECD) spectra data,and compounds 1-2 were further confirmed by single-crystal X-ray diffraction.Bio-logically,compound 5 showed potencies equivalent to sorafenib (IC50 value,9.70 μmol·L-1) against HepG2 cells.The Hoechst 33342 staining,JC-1 fluorescent dye and Annexin V/PI analysis studies demonstrated that 5 can induce apoptosis and attenuate mitochon-drial membrane potential (MMP) in HepG2 cells.
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