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Objective: To evaluate the clinical value of laparoscopic inguinal hernia repair in hernioplasty and simultaneous cholecystectomy. Methods: Twenty-eight patients with symptomatic chronic calculous cholecystitis and synchronous unilateral primary inguinal hernia were performed combined surgery between October 2001 and March 2005. Of them, 10 cases underwent laparoscopic totally extraperitoneal mesh hernia repair (TEP) and laparoscopic cholecystectomy (LC), 3 cases underwent laparoscopic transabdominal preperitoneal mesh hernia repair (TAPP) and LC, and 15 cases underwent LC and open tension-free hernia repair. Results: All the procedures were performed successfully, 2 patients occurred urinary retention in LC+open group and 1 patient occurred scrotum seroma in LC+TEP procedures. During the 6 to 24 months follow-up, no hernia recurrences occurred in all patients. There were 6 Patients (40%) in LC +open group had discomfort pain in the inguinal region and lasted 1 to 3 months. The operating time was longer in the totally laparoscopic group (TEP+LC and TAPP+LC) (104±31 min) than in the LC+open group (80±28 min) (P＜0.05). The intensity of postoperative pain at rest was greater in the LC+open group at 24 h (P＜0.05) and 48 h (P＜0.05). No differences between the 2 groups were found in the mean operating costs and oral intake of the postoperative period. But the time resume to walking (2.9 vs 1. 8 d) (P＜0.01) and the mean hospital stay (8.2 vs 4.6 d) (P＜0. 001) was longer in the LC+open group than in the totally laparoscopic group. Conclusion: In the same operating costs, the totally laparoscopic precedure has more advantages of low postoperative pain, quicker resume to walking and less hospital stay than open tension-free hernia repair in hernioplasty and simultaneous LC. Thus, the totally laparoscopic approach is considered to be advantage of the hernioplasty and simultaneous LC.