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目的观察行气健脾法联合西药治疗肝硬化合并糖代谢异常伴自发性腹膜炎的临床疗效。方法将60例肝硬化合并糖代谢异常伴自发性腹膜炎患者随机分为观察组和对照组,每组30例。观察组采用行气健脾法,方选七味白术散加减,联合头孢三代抗生素抗感染、胰岛素及对症支持的西药治疗,对照组单用西药治疗,疗程均3周。观察2组治疗前后腹水白细胞(WBC)、多形核白细胞(PMN)、细菌培养、李凡他试验数据变化情况,比较2组临床治疗效果。结果治疗后,观察组总有效率为82.23%,高于对照组的67.56%(P<0.05)。2组WBC、PMN、细菌培养阳性例数、李凡他试验阳性例数较治疗前均改善(P<0.05);且观察组改善情况优于对照组(P<0.05)。结论行气健脾法联合西药治疗肝硬化合并糖代谢异常伴自发性腹膜炎疗效优于单用西药。
Objective To observe the clinical effects of qi qi spleen combined with western medicine in the treatment of cirrhosis complicated with abnormal glucose metabolism and spontaneous peritonitis. Methods Sixty patients with cirrhosis with abnormal glucose metabolism and spontaneous peritonitis were randomly divided into observation group and control group, with 30 cases in each group. The observation group was treated with qi and invigorating the spleen method, the prescription of Qiweibaibutansan addition and subtraction, combined with three generations of antibiotics against cephalosporins, insulin and symptomatic western medicine treatment, the control group with western medicine alone, the course of treatment was 3 weeks. The changes of experimental data of ascites, WBC, PMN, bacterial culture and Li Fan in both groups before and after treatment were observed. The clinical effects of the two groups were compared. Results After treatment, the total effective rate in the observation group was 82.23%, which was higher than that in the control group (67.56%, P <0.05). The positive rate of WBC, PMN, bacterial culture in both groups was significantly higher than that before treatment (P <0.05), and the improvement in observation group was better than that in control group (P <0.05). Conclusion qi qi spleen method combined with Western medicine in the treatment of cirrhosis with abnormal glucose metabolism with spontaneous peritonitis is better than single western medicine.