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目的研究阻塞性黄疸患者外周血淋巴细胞白细胞介素-10(IL-10)、白细胞介素-2(IL-2)水平和血浆中前列腺素E2(PGE2)水平的变化,同时观察消炎痛对上述指标的影响。方法给阻塞性黄疸患者口服消炎痛(25mg,1次/8小时),用药前和用药后7d取外周血,分别用放射免疫和ELISA法测血浆中PGE2水平及外周血淋巴细胞IL-10、IL-2水平。结果用药前阻塞性黄疸患者血浆中PGE2水平及外周血淋巴细胞IL-10水平较正常人明显升高,而IL-2水平明显下降,且IL-10、IL-2的水平与PGE2水平显著相关;用药后,患者血淋巴细胞IL-2水平明显升高,而IL-10水平及血浆中PGE2水平明显下降,与用药前相比差异有统计学意义。结论阻塞性黄疸患者淋巴细胞IL-10、IL-2水平的变化与其血浆中PGE2水平升高有关,消炎痛能够明显缓解这种作用。
Objective To study the changes of interleukin-10 (IL-10), interleukin-2 (IL-2) and plasma prostaglandin E2 (PGE2) levels in patients with obstructive jaundice and to observe the effects of indomethacin The impact of the above indicators. Methods Patients with obstructive jaundice were treated with oral indomethacin (25 mg once a day for 8 hours). Peripheral blood was taken before and 7 days after treatment. The levels of plasma PGE2 and IL-10 in peripheral blood were measured by radioimmunoassay and ELISA respectively. IL-2 levels. Results Before treatment, the levels of PGE2 in plasma and IL-10 in peripheral blood lymphocytes in patients with obstructive jaundice were significantly higher than those in normal controls, while IL-2 levels were significantly decreased, and the levels of IL-10 and IL-2 were significantly correlated with PGE2 ; After treatment, the levels of IL-2 in the blood lymphocytes of patients were significantly increased, while the level of IL-10 and the level of PGE2 in plasma were significantly lower than those before treatment. Conclusion The changes of IL-10 and IL-2 levels in lymphocytes in patients with obstructive jaundice are related to the increase of plasma PGE2 levels, and indomethacin can significantly relieve this effect.