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以抗瘤酮 A_(10)和 AS_(2-5)为先导化合物,设计合成了15个谷氨酰胺的衍生物。初步抑瘤试验结果表明,化合物3、6、8、9和10对小鼠肉瘤 S180有较好的抑制作用,抑制率达30.3～64%.
With anti-tumor ketones A_ (10) and AS_ (2-5) as the lead compounds, 15 glutamine derivatives were designed and synthesized. The results of preliminary antitumor experiments showed that compounds 3, 6, 8, 9 and 10 had better inhibitory effect on mouse sarcoma S180 with the inhibitory rate of 30.3-64%.