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以骨形态发生蛋白(BMP)的单克隆抗体ABC法,对36例骨肿瘤、12例软组织肿瘤进行免疫组化染色。结果12例软组织肿瘤阴性(纤维瘤2例,横纹肌肉瘤3例,平滑肌肉瘤7例),骨肿瘤阳性占89%(除外1例骨的恶性纤维组织细胞瘤,1例软骨肉瘤和2例间叶性软骨肉瘤)。认为:①BMP-McAb可用于区分肿瘤是否起源于成骨性结缔组织;②鉴于许多骨肿瘤皆有BMP,但生物学检测只有骨肉瘤、软骨肉瘤和骨样骨瘤有骨生成反应,提出可能和BMP含量有关,并认为免疫组化法优于生物学检测。
Using bone morphogenetic protein (BMP) monoclonal antibody ABC method, 36 cases of bone tumors and 12 cases of soft tissue tumors were immunohistochemically stained. Results Twelve cases of soft tissue tumors were negative (2 cases of fibroids, 3 cases of rhabdomyosarcoma, 7 cases of leiomyosarcoma), and 89% of bone tumors were positive (except 1 case of malignant fibrous histocytoma of bone, 1 case of chondrosarcoma and 2 cases of interstitial Sex chondrosarcoma). It is thought that: 1BMP-McAb can be used to distinguish whether the tumor originated from osteogenic connective tissue; 2 Given that many bone tumors have BMP, only osteosarcoma, chondrosarcoma, and osteoid osteoma have osteogenic response, suggesting possible and The content of BMP is related and it is considered that immunohistochemistry is superior to biological detection.