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公布号:CN105044269A公布日:2015.11.11申请人:成都百裕科技制药有限公司摘要:本发明公开了反相高效液相色谱检测阿哌沙班中起始物料Ⅱ的方法,它包括以下步骤:(1)制备供试品溶液;(2)采用反相高效液相色谱对供试品进行检测;(3)按面积归一化法计算供试品中单个杂质和总杂质的含量。本发明
Publication date: 2015.11.11 Applicant: Chengdu Baoyu Science and Technology Pharmaceutical Co., Ltd. Abstract: The invention discloses a method for detecting starting material II of apixaban by reversed-phase high performance liquid chromatography, which comprises the following steps: (1) Preparing the test solution; (2) Testing the test sample by RP-HPLC; (3) Calculating the content of the single impurity and the total impurity in the test sample according to the area normalization method. this invention