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近年来多项研究结果显示,动脉粥样硬化性病变与肿瘤发生存在共同的发病机制,即均伴有血小板激活并诱导COX过度表达,后者作用并导致上皮及内皮细胞功能障碍,进而引发心血管疾病和肿瘤的发生发展。5项阿司匹林与结直肠癌相关性研究的汇总分析显示,小剂量阿司匹林能显著降低结直肠癌的发生率和致死率,由此我们推知小剂量阿司匹林对结直肠癌和动脉硬化血栓形成可能具有类似的预防机制,即阿司匹林通过抑制血小板的激活及COX的作用预防动脉硬化血栓形成和肿瘤发生。小剂量阿司匹林对心血管疾病和结直肠癌的预防机制主要为抑制COX途径,后者可分为COX依赖性和非COX依赖性机制。
In recent years, a number of studies have shown that atherosclerotic lesions and tumorigenesis have a common pathogenesis, which are associated with platelet activation and induce COX overexpression, the latter effect and lead to epithelial and endothelial dysfunction, which in turn lead to heart Vascular diseases and tumor development. A pooled analysis of five aspirin-colorectal cancer-related studies shows that low-dose aspirin can significantly reduce the incidence and mortality of colorectal cancer, so we infer that low-dose aspirin may have similar effects on colorectal cancer and atherothrombosis Aspirin prevents thrombosis and tumorigenesis of arteriosclerosis by inhibiting the activation of platelets and the action of COX. Low-dose aspirin on cardiovascular disease and colorectal cancer prevention mechanisms mainly inhibit the COX pathway, the latter can be divided into COX-dependent and non-COX-dependent mechanisms.