新近克隆出来的Ras相关区域家族1A基因(RASSF1A)已被确认为一种候选抑癌基因(TSGs),位于人类染色体3p21.3上。RASSF1A基因失表达见于多种人类肿瘤中,如肺癌、乳腺癌、肝癌、宫颈癌、肾癌等,表明了其在致癌作用中的重要性。高度甲基化和微卫星变异(mic-rosatellite alterations)是导致RASSF1A基因失活的主要机制,其参与了细胞凋亡信号的转导、微管的稳定作用和有丝分裂的进程,作为一种Ras负向调节因子阻止细胞生长,诱导细胞凋亡,促进肿瘤的发生和发展。宫颈癌中存在RASSF1A基因的表达缺失,且与人乳头状瘤病毒(HPV)感染之间存在一定的相关关系。 Recently cloned Ras-related region family 1A gene (RASSF1A) has been identified as a candidate tumor suppressor gene (TSGs), located on the human chromosome 3p21.3. RASSF1A gene loss of expression found in a variety of human tumors, such as lung cancer, breast cancer, liver cancer, cervical cancer, kidney cancer, showed its importance in carcinogenesis. Hypermethylation and mic-rosatellite alterations are the major mechanisms that lead to the inactivation of the RASSF1A gene, which is involved in the transduction of apoptotic signals, the stabilization of microtubules and the mitotic progression as a Ras negative Regulators to prevent cell growth, induce apoptosis and promote the occurrence and development of tumors. There is a lack of expression of RASSF1A gene in cervical cancer, and there is a certain correlation between it and human papillomavirus (HPV) infection.