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目的 :探讨放射治疗 (放疗 )对食管癌患者机体免疫功能的影响。方法 :采用单扩散 (SRID)法、酵母花环法检测 6 5例食管癌患者血清免疫球蛋白水平、外周血T淋巴细胞亚群和红细胞免疫功能。结果 :放疗后食管癌患者免疫球蛋白无明显变化(P >0 .0 5 ) ;与放疗前相比 ,总T细胞 (CD3+ )无明显降低 (P >0 .0 5 ) ,CD4 + T细胞明显下降 (P <0 .0 1) ,CD8+ T细胞上升(放疗后 3个月时 ) (P <0 .0 5 ) ;CD4 + /CD8+ 明显低于放疗前 (P <0 .0 1) ,一直延续到放疗后 6个月 (P <0 .0 1) ;与放疗前比较 ,红细胞C3b受体花环 (RBCC3bRR)明显下降 (P <0 .0 1) ,红细胞免疫复合物花环 (RBCC3bICR)无明显变化。结论 :食管癌患者放疗后 ,免疫功能受损或抑制 ,调节功能紊乱还会持续一段时间 ,增加宿主对抗肿瘤的功能 ,放疗的同时就增加免疫治疗 ,以提高患者的免疫能力
Objective: To investigate the effect of radiotherapy (radiotherapy) on the immune function of esophageal cancer patients. Methods: Serum immunoglobulin, T lymphocyte subsets and erythrocyte immune function in 65 cases of esophageal cancer were detected by the method of single diffusion (SRID) and yeast wreath method. Results: There was no significant change in immunoglobulin in patients with esophageal cancer after radiotherapy (P> 0.05). Compared with those before radiotherapy, there was no significant decrease in total T cells (CD 0 +), CD4 + T cells (P <0.01), CD8 + T cells increased (3 months after radiotherapy) (P <0.05), CD4 + / CD8 + was significantly lower than that before radiotherapy (P <0.01) (P <0. 01). Compared with those before radiotherapy, the erythrocyte C3b receptor rosette (RBCC3bRR) was significantly decreased (P <0.01), the erythrocyte immune complex rosette (RBCC3bICR) was obvious change. Conclusion: After radiotherapy, the immune function is impaired or inhibited in esophageal cancer patients. The disorder of regulatory function will continue for a period of time, increasing the function of the host against tumor. At the same time, radiotherapy will increase the immunotherapy to improve the immunocompetence