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目的:了解呼吸道合胞病毒下呼吸道感染(RSV-LRTI)住院患儿的临床特点,探讨其治疗及转归。方法:回顾性分析2010年1月至2013年12月住院的RSV-LRTI患儿的临床和病原学资料。结果:RSV-LRTI患儿共613例,其中男393例,女220例,年龄2个月~6岁,>6个月患儿351例,占57.2%;121例(19.7%)有基础疾病,以先天性心脏病最多见,其次为早产和(或)低出生体质量。613例患儿均进行痰培养检查,245例行肺炎支原体抗体检测,15例行血培养检查。痰液中共检出细菌75株,其中革兰阴性菌48株(64.0%);血培养1例阳性。503例使用抗生素,以头孢菌素类最多,占63.0%;单药治疗占62.6%,二联用药占19.4%。治疗时间<1周208例(33.9%),1~2周357例(58.2%)。治愈498例(81.2%),好转103例(16.8%),未愈自动出院12例(2.0%),无死亡病例。结论:丽水地区RSV-LRTI主要见于6个月以下婴儿,19.7%合并有基础疾病,12.3%合并细菌感染,以革兰阴性菌感染最常见;63.0%使用头孢菌素治疗,多为单药治疗,疗程1~2周。
Objective: To understand the clinical characteristics of infants with respiratory syncytial virus (RSV-LRTI) hospitalization and to explore the treatment and prognosis. Methods: The clinical and etiological data of children hospitalized with RSV-LRTI from January 2010 to December 2013 were retrospectively analyzed. Results: A total of 613 children with RSV-LRTI were enrolled in this study, including 393 males and 220 females. There were 351 cases (57.2%) of children aged 2 months to 6 years and> 6 months. 121 cases (19.7%) had underlying diseases , With the most common congenital heart disease, followed by preterm birth and / or low birth weight. 613 children were sputum culture examination, 245 cases of Mycoplasma pneumoniae antibody test, 15 cases of blood culture examination. A total of 75 bacterial strains were detected in sputum, of which 48 strains were Gram-negative bacteria (64.0%), one was positive in blood culture. 503 cases of antibiotics to cephalosporins most, accounting for 63.0%; monotherapy 62.6%, two drugs accounted for 19.4%. Treatment time was <1 week, 208 cases (33.9%), 1 to 2 weeks, 357 cases (58.2%). 498 cases (81.2%) were cured, 103 cases (16.8%) were improved, 12 cases (2.0%) were discharged automatically and no deaths were found. Conclusions: RSV-LRTI in Lishui mainly occurs in infants less than 6 months old, with 19.7% with underlying diseases and 12.3% with bacterial infections, most commonly with Gram-negative bacteria. 63.0% are treated with cephalosporins and are mostly monotherapy , Treatment for 1 to 2 weeks.