Background Wide excision is considered the treatment of endometriosis.It is difficult to surgeon for reconstruction of a large full-thickness defect through the abdominal-wall.We introduce a method of mini-abdominoplasty combined with mesh that can be used for reconstruction of a large full-thickness defect through the abdominal-wall after wide excision of abdominal wall endometriosis.Methods This retrospective study includes a series of patients who underwent wide excision of abdominal wall endometriosis and reconstruction of a large full-thickness defect through the abdominal-wall over a 5-year period.Information obtained from chart reviews includes age,size of lesion and defect,complications and revisions.Results The method was used for 8 patients including 2 patients with recurrence.The mean size of the masses was (3.5±2.0) cm.The mean size of the fascia defects was 7.1 cm x 8.6 cm.The mean length of follow-up was (24±12)months.There was no recurrence,no hernia,and no other complications.The technique generated only a horizontal scar.The scar and contour of the lower abdomen provided a more pleasant appearance than the traditional procedure.Conclusions Mini-abdominoplasty combined with mesh is a useful and acceptable reconstruction method for large full-thickness defects through the abdominal wall after endometriosis resection.It is feasible for wide excision with 1 cm normal tissues around the margin.It provides an aesthetically pleasing result.