Objective:To determine the susceptibility and irritability level of malaria vector Anopheles sacharovi(An.sachrovi) to different insecticides in a malaria-prone area.Methods:Susceptibility and irritability levels of field collected strain of An.sacharovi to WHO standard papers of DDT 4%,dieldrin 0.4%,malathion 5%,fenitrothion 1%,permethrin 0.75%,and deltamethrin 0.05% were determined in East Azerbaijan of Iran during reemerging of malaria as described by WHO.Results:Results showed that at the diagnostic dose of insecticides this species exhibited resistance to DDT,tolerant to dieldrin and but somehow susceptible to fenitrothion,malathion, permethrin and deltamethrin.The results of irritability of this species to DDT,lambdacyhalothrin. permethrin cyfluthrin and deltamethrin revealed that DDT had had the most and deltamethrin the least irritancy effect.The average number of take offs/fly/minules for DDT was 0.8±0.2.The order of irritability for permethrin,lambdacyhalothrin,cyfluthrin and deltamethrin were 0.7±0.2,0.5±0.2, 0.5±0.3,and 0.2±0.1,respectively.Conclusions:Results of this study reveals the responsiveness of the main malaria vector to different insecticides.This phenomenon is depending on several factors such as type and background of insecticide used previously,insecticide properties,and physiology of the species.Careful monitoring of insecticide resistance and irritability level of species could provide a clue for appropriate selection of insecticide for malaria control. Objective: To determine the susceptibility and irritability levels of malaria vector Anopheles sacharovi (An.sachrovi) to different insecticides in a malaria-prone area. Methods: Susceptibility and irritability levels of field collected strain of An.sacharovi to WHO standard papers of DDT 4 %, dieldrin 0.4%, malathion 5%, fenitrothion 1%, permethrin 0.75%, and deltamethrin 0.05% were determined in East Azerbaijan of Iran during reemerging of malaria as described by WHO. Results: Results showed that at the diagnostic dose of insecticides this species resistance to DDT, tolerant to dieldrin and but somehow susceptible to fenitrothion, malathion, permethrin and deltamethrin. the results of irritability of this species to DDT, lambdacyhalothrin. permethrin cyfluthrin and deltamethrin revealed that DDT had had the the most and deltamethrin the least irritancy effect. The average number of take offs / fly / minules for DDT was 0.8 ± 0.2. the order of irritability for permethrin, lambdacyhalothrin, cyfluthrin an d deltamethrin were 0.7 ± 0.2, 0.5 ± 0.2, 0.5 ± 0.3, and 0.2 ± 0.1, respectively. Conclusions: Results of this study reveals the responsiveness of the main malaria vector to different insecticides. This phenomenon is depending on several factors such as type and background of insecticide used previously, insecticide properties, and physiology of the species. Careful monitoring of insecticide resistance and irritability level of species could provide a clue for Appropriate selection of insecticide for malaria control.