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目的:探究拉莫三嗪群体药代动力学研究现状及影响因素探究。方法:对近些年国内外拉莫三嗪的研究文献进行有效的收集,对资料进行归纳整理和对比分析,记录和对比最新的研究现状,以及探究拉莫三嗪药代动力学的影响因素。结果:在研究现状方面,拉莫三嗪的吸收、分布、代谢、排泄过程均研究的较为全面;主要的影响因素有药物相互作用、年龄及体质量、基因多态性三项内容。结论:临床上应用拉莫三嗪进行用药治疗时应该充分考虑该药的药代动力学以及其在发挥药效作用过程中的影响因素,制定出合理的给药方案。
Objective: To investigate the current status and influential factors of lamotrigine group pharmacokinetics. Methods: The literature of lamotrigine at home and abroad was collected effectively in recent years, the information was summarized and compared, the latest research status was recorded and compared, and the influencing factors of pharmacokinetics of lamotrigine . Results: In the research status, the study of absorption, distribution, metabolism and excretion of lamotrigine is more comprehensive. The main influencing factors are drug interactions, age, body mass and gene polymorphism. Conclusion: The clinical application of lamotrigine should take full account of the pharmacokinetics of the drug and its influencing factors in the process of exerting the efficacy, and formulate a reasonable dosing regimen.