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目的比较焦炉工和非职业暴露人群尿中1羟基芘的不同水平,并探讨可能的各种影响因素。方法2002年上半年,以某焦化厂265名炼焦作业工人和226名非职业接触对照人群为调查对象,职业接触组收集工作班末尿,对照组收集晨尿。根据环境中多环芳烃监测和调查表评价外暴露因素和可能的混杂因素,采用高效液相色谱法测定尿中1羟基芘含量,比较两组人群尿中1羟基芘的不同水平,并分析外暴露等级、吸烟、饮酒、年龄和体重指数的可能影响。结果尿中1羟基芘浓度呈炉顶工>炉侧工>炉底工>对照的趋势,几何均数依次为13.49、6.56、1.38和0.35μmol/mol肌酐,差异有统计学意义;各组人群尿中1羟基芘浓度超标率分别依次为94.81%、84.73%、35.09%和0.88%,差异有统计学意义。对照人群中≥20支/d吸烟组的尿中1羟基芘水平明显高于不吸烟组,修正几何均数分别为0.47和0.31μmol/mol肌酐,差异有统计学意义;对照人群中饮酒组的尿中1羟基芘水平明显低于不饮酒组,修正几何均数分别为0.33和0.47μmol/mol肌酐,差异有统计学意义。结论焦炉工尿中1羟基芘水平较高,以炉侧工和炉顶工最为明显,非职业暴露人群尿中1羟基芘本底水平与吸烟和饮酒因素有关。
Objective To compare the different levels of urinary 1hydroxy-pyrene in coke oven workers and non-occupationally exposed people and to explore various possible influencing factors. Methods In the first half of 2002, a total of 265 coking workers and 226 non-occupational exposure control cohorts from a coking plant were surveyed. Occupational exposure groups collected urine from work shifts and morning urine from control subjects. According to the environmental PAH monitoring and questionnaire evaluation of external exposure factors and possible confounding factors, the content of 1-hydroxy-pyrene in urine was determined by HPLC, and the levels of urinary 1-hydroxy-pyrene in both groups were compared and analyzed Exposure levels, smoking, alcohol consumption, age, and possible effects of BMI. Results The concentration of 1-hydroxypyrene in urine showed a tendency of top-firing, side-firing and bottom-burning, and the geometric mean was 13.49, 6.56, 1.38 and 0.35 μmol / mol creatinine, The urinary 1hydroxypyrene concentration exceeded the standards of 94.81%, 84.73%, 35.09% and 0.88%, respectively, with statistical significance. The urinary 1hydroxypyrene level in ≥20 cigarettes per day in control group was significantly higher than that in non-smoking group, the corrected geometric mean were 0.47 and 0.31μmol / mol creatinine, respectively, with significant difference; in control group, The level of urinary 1-hydroxy-pyrene was significantly lower than that of the non-alcohol group, with the corrected geometric mean values of 0.33 and 0.47μmol / mol creatinine, respectively. The difference was statistically significant. Conclusions Coke oven workers have higher levels of urinary 1-hydroxy-pyrene with the most obvious side-firing and top-firing workers. The urinary levels of 1-hydroxy-pyrene in non-exposed workers are related to smoking and drinking factors.