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目的 揭示加味真武汤对充血性心力衰竭(CHF)少阴病阳虚水停证兔血流动力学的影响。方法 先给兔灌服寒凉药7 d,再结扎冠状动脉,缩窄升主动脉口径,建立CHF少阴病阳虚水停证兔模型,设立中药组、西药组、中西药结合组及空白组,观察比较治疗后各组兔的心率及血流动力学指标。结果 给药1 min后,西药组、中西药组出现心率减慢,左室内压、左室内压最大上升速率降低,与中药组及空白组比较具有显著差异(P<0.05),中药组5 min时才出现上述变化,与西药组及中西药组对比无统计学意义上的差异,与空白组对比具有显著差异(P<0.05)。结论 加味真武汤能减慢CHF少阴病阳虚水停证兔的心率,降低其左室内压及左室内压最大上升速率,但其作用较缓慢。
Objective To reveal the effect of Jiawei Zhenwu Decoction on the hemodynamics of rabbits with congestive heart failure (CHF), yin deficiency and Yang deficiency syndrome. Methods Rabbits were given cold medicine for 7 days, then the coronary arteries were ligated, and the aorta diameter was shortened. A rabbit model of CHF yin deficiency and water deficiency syndrome was established. The Chinese medicine group, western medicine group, western medicine combination group and blank were established. Group, observe and compare the heart rate and hemodynamic parameters of each group after treatment. Results After 1 min administration, the heart rate of western medicine group and western medicine group slowed down, and the left ventricular pressure and left ventricular systolic maximum increase rate decreased. There was a significant difference compared with traditional Chinese medicine group and blank group (P<0.05). The changes mentioned above did not appear to be statistically significant when compared with the western medicine group and the Chinese and Western medicine groups, and there was a significant difference from the blank group (P<0.05). Conclusion Jiawei Zhenwu Decoction can slow down the heart rate of CHF Shaoyin Yang deficiency water-suppressed rabbits, and reduce the left ventricular pressure and the maximum increase rate of left ventricular pressure, but its effect is slow.