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目的探讨急性脑梗死患者与血浆纤维蛋白原含量之间的关系。方法检测84例急性脑梗死患者及80例正常对照者血浆中纤维蛋白原含量,与神经功能受损程度进行相关分析。结果急性脑梗死患者急性期与恢复期纤维蛋白原均显著高于对照组(P<0.01),纤维蛋白原浓度与神经功能缺损程度评分呈显著正相关(P<0.01)。结论急性脑梗死患者纤维蛋白原浓度升高,可能参与了缺血性脑损伤的病理过程,并间接反映病性程度。
Objective To investigate the relationship between plasma levels of fibrinogen and patients with acute cerebral infarction. Methods The plasma levels of fibrinogen in 84 patients with acute cerebral infarction and 80 normal controls were detected and their correlation with the degree of neurological impairment was analyzed. Results The levels of fibrinogen in acute and convalescent patients with acute cerebral infarction were significantly higher than those in the control group (P <0.01). There was a significant positive correlation between fibrinogen concentration and neurological deficit score (P <0.01). Conclusion The concentration of fibrinogen in patients with acute cerebral infarction may be involved in the pathological process of ischemic brain injury and indirectly reflect the degree of fibrosis.