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目的:观察塞来昔布对急性胰腺炎(AP)患者肝损伤的保护作用。方法:选取2013-04-2015-09我院收治的AP患者80例,使用数字法随机分为常规治疗组(对照组)和塞来昔布治疗组(观察组),每组40例。ELISA法检测丙氨酸转氨酶(ALT)、天门氨酸氨基转移酶(AST)、肿瘤坏死因子-α(TNF-α)和白介素-1(IL-1),比较2组临床疗效。结果:治疗前2组ALT、AST、TNF-α和IL-1表达比较差异无统计学意义(P>0.05)。治疗7d后2组ALT、AST、TNF-α和IL-1表达均降低(P<0.05,P<0.01),且观察组的ALT、AST、TNF-α和IL-1水平均低于对照组(P<0.05,P<0.01)。对照组腹痛、腹胀缓解时间、排气、通便时间、体温恢复正常时间以及住院时间分别为:(5.23±1.22)d、(5.41±1.26)d、(4.92±1.07)d和(17.66±4.35)d,均显著高于观察组的(3.68±0.82)d、(3.95±0.93)d、(4.02±0.87)d和(11.71±2.84)d(P<0.05)。观察组的临床治疗有效率为90.0%(36/40),显著优于对照组的72.5%(29/40)(P<0.05)。结论:塞来昔布抑制AP患者炎症反应,保护肝功能,临床疗效显著。
Objective: To observe the protective effect of celecoxib on liver injury in patients with acute pancreatitis (AP). Methods: Eighty AP patients admitted to our hospital from 2013-04-2015-09 were randomly divided into routine treatment group (control group) and celecoxib treatment group (observation group), 40 cases in each group. The serum levels of ALT, AST, TNF-α and IL-1 were measured by ELISA. The clinical efficacy of the two groups were compared. Results: There was no significant difference in the expression of ALT, AST, TNF-α and IL-1 between the two groups before treatment (P> 0.05). The levels of ALT, AST, TNF-α and IL-1 in the two groups were decreased after treatment for 7 days (P <0.05, P <0.01), and the levels of ALT, AST, TNF-α and IL-1 in the observation group were lower than those in the control group (P <0.05, P <0.01). The abdominal pain, abdominal distension time, excretion, laxative time, body temperature recovery time and hospital stay in the control group were (5.23 ± 1.22) d, (5.41 ± 1.26) d, (4.92 ± 1.07) d and (17.66 ± 4.35 ) d were significantly higher than those in the observation group (3.68 ± 0.82) d, (3.95 ± 0.93) d, (4.02 ± 0.87) d and (11.71 ± 2.84) d, respectively (P <0.05). The clinical efficacy of the observation group was 90.0% (36/40), which was significantly better than that of the control group (72.5%, 29/40) (P <0.05). Conclusion: Celecoxib can inhibit the inflammatory response of AP patients and protect the liver function. The clinical curative effect is obvious.