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目的:回顾分析2型糖尿病性白内障术后血清唾液酸(SA)浓度与黄斑水肿的相关性。方法:选取2015年1月至2016年1月深圳市第二人民医院收治的40例2型糖尿病性白内障患者,采取外周静脉血后用比色法测量血清SA浓度,按SA浓度分组,高于正常值(观察组)20例,正常SA浓度(对照组)20例。全部患者血糖浓度均控制在8 mmol/L以下,行超声乳化白内障摘除及人工晶体植入术,所有患者术前术后行眼底荧光血管造影检查,记录有无黄斑水肿及水肿程度。结果:观察组20例平均血清SA浓度为(121.09±10.21)mmol/L,术后发生黄斑水肿4例,占20%,其中0级水肿2例,1级水肿1例,2级水肿1例;对照组血清SA浓度为(85.64±9.49)mmol/L,术后黄斑水肿1例,占5%。两组术后黄斑水肿的发生率比较,差异具有统计学意义(P<0.05)。结论:糖尿病性白内障患者血清SA浓度越高,白内障术后黄斑水肿发生率越高,血清SA浓度在一定程度上反映糖尿病性黄斑水肿(DME)的发生情况。
Objective: To investigate the correlation between serum sialic acid (SA) and macular edema after type 2 diabetic cataract surgery. Methods: From January 2015 to January 2016, 40 cases of type 2 diabetic cataract patients admitted to Second People’s Hospital of Shenzhen City were enrolled in this study. Serum SA concentrations were measured by colorimetry after peripheral blood was taken and grouped by SA concentration Normal (observation group) 20 cases, normal SA concentration (control group) 20 cases. All patients under the control of blood glucose concentrations below 8 mmol / L, phacoemulsification cataract extraction and intraocular lens implantation, all patients underwent fundus fluorescein angiography before and after surgery to record the degree of macular edema and edema. Results: In the observation group, the average serum SA concentration was (121.09 ± 10.21) mmol / L in 20 cases, and macular edema occurred in 4 cases (20%). There were 2 cases of grade 0 edema, 1 case of grade 1 edema and 1 case of grade 2 edema ; The control group serum SA concentration (85.64 ± 9.49) mmol / L, postoperative macular edema in 1 case, 5%. The incidence of postoperative macular edema between the two groups, the difference was statistically significant (P <0.05). Conclusion: The higher the concentration of serum SA in patients with diabetic cataract, the higher the incidence of macular edema after cataract surgery. The serum SA concentration to a certain extent reflects the occurrence of diabetic macular edema (DME).