本文综述了WEC方法中有关培养基、代谢活化系统和胚胎发育的形态学评价方面的若干进展,对该法在致畸物筛检、致畸作用机理等研究中的应用作了概要介绍。从研究现状来看,该法是目前在致畸物或致畸因素筛检中一种较好的体外方法,尤其是在致畸作用机理研究方面有独特的价值;但无论是方法学还是应用方面都有待于改进和发展。 This review summarizes some advances in morphological evaluation of culture medium, metabolic activation system and embryo development in WEC method. The application of this method in the study of teratogen screening and teratogenic mechanism is summarized. Judging from the research status quo, this method is a good in vitro method in the screening of teratogen or teratogenic factors, especially in the study of mechanism of teratogenic effects; however, whether it is methodology or application All aspects need to be improved and developed.