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1980～1981年,我们研究了云南省宣威县肺癌高发地区农民室内的煤烟尘的致癌作用。实验用昆明种小鼠,皮下注射环已烷的提取物,分四组:溶剂对照组,500毫克提取物和1000毫克提取物组、及2毫克B(a)P组,动物数分别为38、57、56和38只,经10个月的观察,各组肺癌(包括鳞癌、腺鳞癌和腺癌)的发生率依次为2.6%(1/38)、77.2%(44/57)、64.3%(36/56)和15.8%(6/38);肺肿瘤(包括肺癌、纤维肉瘤和腺瘤)总发生率依次为15.8%(6/38)、82.5%(47/57)、73.2%(41/56)和34.2%(13/38)。次之为注射部位肿瘤,其中B(a)P组小鼠的皮下纤维肉瘤发生率达84.2%(32/38)。除少数胸腺瘤外,未发现其他部位肿瘤。结果表明煤烟尘提取物含有很强的致肺癌物质,这和宣威人群中肺癌高发的原因可能有关。
From 1980 to 1981, we studied the carcinogenic effects of coal smoke in farmers’ houses in areas with high incidence of lung cancer in Xuanwei County, Yunnan Province. Experimental Kunming mice were subcutaneously injected with cyclohexane extracts and divided into four groups: solvent control group, 500 mg extract and 1000 mg extract group, and 2 mg B(a)P group, and the number of animals was 38. , 57, 56 and 38, after 10 months of observation, the incidence of lung cancer (including squamous cell carcinoma, adenosquamous carcinoma and adenocarcinoma) in each group was 2.6% (1/38), 77.2% (44/57) , 64.3% (36/56) and 15.8% (6/38); the total incidence of lung cancer (including lung cancer, fibrosarcoma, and adenoma) was 15.8% (6/38), 82.5% (47/57), respectively. 73.2% (41/56) and 34.2% (13/38). Followed by the tumor at the injection site, the incidence of subcutaneous fibrosarcoma in the B(a)P group was 84.2% (32/38). Except for a few thymomas, no other tumors were found. The results showed that the coal smoke extract contains very strong lung cancer substances, which may be related to the high incidence of lung cancer in the Xuanwei population.