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通过建立臂丛节前损伤的模型,观察撕脱的背根神经节通过相连的外周神经是否对相应的骨骼肌有延缓萎缩的作用,以期寻找防止肌萎缩的方法。方法:选用雄性成年SD大鼠60只,随机分成2组。实验组:制成C_5C_6根性撕脱的模型,使拖出椎孔的背根神经节仅通过肌皮神经与完全失神经支配的肱二头肌有联系。对照组:于椎孔外切断C_5C_6神经根,并造成肱二头肌完全失神经支配。于术后1、2、3、4和5个月各时间段,分别测定肱二头肌纤颤电位波幅、肌张力、肌湿重、肌纤维截面积并观察背根神经节中感觉神经元的变化。结果:术后1～5个月背根神经节中均见到存活的感觉神经元;纤颤电位波幅实验组大于对照组;实验组肌张力于术后1、2个月时明显优于对照组;术后1、2、3个月,实验组的肌湿重、肌纤维截面积明显高于对照组。结论:在节前损伤1～3个月内,背根神经节中感觉神经元有延缓失神经支配骨骼肌萎缩的作用。
By establishing a model of pre-brachial plexus injury, we observed whether the avulsed dorsal root ganglia could delay the atrophy of the corresponding skeletal muscle through the connected peripheral nerves in order to find a way to prevent muscle atrophy. Methods: Sixty male adult SD rats were randomly divided into two groups. Experimental group: A model of C_5C_6 root avulsion was made in which the dorsal root ganglion pulled out of the foramen was connected to the biceps at the time of complete denervation only through the musculocutaneous nerve. In the control group, C_5C_6 nerve roots were cut off outside the foramen, and the biceps femoris was completely denervated. At 1, 2, 3, 4 and 5 months postoperatively, the amplitude of biceps fibrillation, muscle tone, muscle wet weight and cross-sectional area of muscle fiber were measured and the sensory neurons in dorsal root ganglion Variety. RESULTS: Surviving sensory neurons were seen in dorsal root ganglion 1 to 5 months postoperatively. Fibrillation amplitude was higher in experimental group than in control group. Muscle tension in experimental group was significantly better than that in control group Group; at 1, 2, and 3 months after operation, the muscle wet weight and muscle fiber cross-sectional area in the experimental group were significantly higher than those in the control group. Conclusion: Within 1 to 3 months after preganglionic injury, sensory neurons in the dorsal root ganglion may delay denervation and dominate the skeletal muscle atrophy.