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目的观察前列地尔联合羟苯磺酸钙在糖尿病肾病(DN)治疗中的作用。方法将80例早期DN患者随机分为对照组和治疗组各40例。治疗组在糖尿病基础治疗的同时给予前列地尔脂微球注射液10 ml加入生理盐水100 ml中静脉滴注,每日1次,并口服羟苯磺酸钙胶囊0.5 g,每日3次。对照组在糖尿病基础治疗的同时给予丹参注射液20 ml加入生理盐水250 ml中静脉滴注,每日1次。观察两组1个疗程(均为4周)的疗效及治疗前、后的空腹血糖(FPG)、血清总胆固醇(TC)、甘油三酯(TG)、血肌酐(Cr)、尿素氮(BUN)及24 h尿蛋白定量的变化。结果 FPG、TC、TG、Cr、BUN和24 h尿蛋白定量水平在治疗前两组比较差异均无统计学意义(P均>0.05);治疗后较治疗前两组均显著下降(P<0.05或P<0.01);治疗组治疗后均低于对照组治疗后(P均<0.05)。治疗组总体有效率为95.0%明显高于对照组的55.0%(P<0.05)。结论前列地尔与羟苯磺酸钙胶囊联合治疗早期DN,疗效可靠,在延缓DN的进展上可能获益。
Objective To investigate the role of alprostadil in combination with calcium dobesilate in the treatment of diabetic nephropathy (DN). Methods 80 patients with early DN were randomly divided into control group and treatment group, 40 cases each. In the treatment group, 10 ml of alprostadil microspheres injection was added to 100 ml of normal saline intravenously once a day while oral administration of 0.5 g of calcium dobesilate capsules 3 times a day. Control group in the basic treatment of diabetes while given Salvia injection of 20 ml added 250 ml of normal saline intravenously once daily. The effects of one course of treatment (all 4 weeks) and the fasting blood glucose (FPG), serum total cholesterol (TC), triglyceride (TG), serum creatinine (Cr) and blood urea nitrogen ) And 24 h urine protein quantitative changes. Results The levels of FPG, TC, TG, Cr, BUN and 24 h urinary protein in two groups had no significant difference before treatment (P> 0.05), but decreased significantly after treatment Or P <0.01). After treatment, the treatment group was lower than the control group after treatment (all P <0.05). The overall effective rate in the treatment group was 95.0%, which was significantly higher than that in the control group (55.0%, P <0.05). Conclusions Alprostadil and calcium dobesilate in the treatment of early stage DN have reliable curative effect and may be beneficial in delaying the progression of DN.