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应用放射配基结合分析法检测31例肝细胞癌(HCC)及癌旁组织中雄激素受体(AR)的改变。结果HCC癌组织中AR含量为250.36±110.45fmol/mg·P,癌旁组织中AR含量为90.55±31.56fmol/mg·P,HCC癌组织中AR明显高于癌旁组织(P<0.01)。AR含量与血清甲胎球蛋白(AFP)、B型肝炎携带情况及HCC组织学类型无相关性(P>0.05)。AR含量的增加可能与肝细胞的癌变有关,AR可能促进HCC的产生和发展,部分HCC具有雄激素依赖性,为HCC可能的抗雄激素治疗提供了依据。
Radioligand binding assay was used to detect the change of androgen receptor (AR) in 31 cases of hepatocellular carcinoma (HCC) and adjacent tissues. Results The AR content in HCC tissues was 250.36±110.45 fmol/mg·P, and the AR content in adjacent tissues was 90.55±31.56 fmol/mg·P. The AR in HCC tissues was significantly higher than that in adjacent tissues. (P<0.01). There was no correlation between AR content and serum alpha fetoprotein (AFP), hepatitis B carrier status and histological type of HCC (P>0.05). The increase of AR content may be related to the carcinogenesis of hepatocytes. AR may promote the generation and development of HCC. Some HCCs are androgen-dependent, providing a basis for possible anti-androgen treatment of HCC.