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120例2型糖尿病患者根据UACR分为非糖尿病肾脏疾病组40例(UACR<30mg/g)、早期DN组40例(30mg/g≤UACR<300mg/g)、临床DN组40例(UACR≥300mg/g),检测空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、血脂、血钙、血磷、血肌酐及CRP,电化学发光法检测三组血清25(OH)D3水平,采用t检验、Pearson相关分析及Logstic回归分析统计学方法分析。结果三组中随UACR增加,血清25(OH)D3水平逐渐降低,且每两组之间比较均有统计学差异(P均<0.05);而CRP逐渐升高,且每两组之间比较均有统计学差异(P均<0.05);三组中FPG、Hb A1c每两组比较差异均有统计学意义(P均<0.05)。多因素Logstic回归分析显示,血清25(OH)D3水平与FPG、CRP及UACR呈负相关(r分别为-0.352,-0.523,-0.643,P均<0.05),与血钙、血磷、TG及血肌酐无相关性(P均>0.05)。结论 25(OH)D3缺乏可能与2型糖尿病肾病的发生、发展相关,慢性炎症增强可能与25(OH)D3缺乏有关。
According to UACR, 120 patients with type 2 diabetes were divided into non-diabetic renal disease group (UACR <30mg / g), 40 early DN patients (30mg / g≤UACR <300mg / g) and 40 clinical DN patients The level of serum 25 (OH) D3 was detected by electrochemiluminescence. The level of serum 25 (OH) D3 was measured by t test , Pearson correlation analysis and Logstic regression analysis of statistical methods. Results The levels of serum 25 (OH) D3 gradually decreased with the increase of UACR in three groups, and there was a significant difference between the two groups (P <0.05), while CRP increased gradually (P <0.05). There was significant difference in FPG and Hb A1c between the two groups (P <0.05). Logistic regression analysis showed that the level of serum 25 (OH) D3 was negatively correlated with FPG, CRP and UACR (r = -0.352, -0.523, -0.643, P <0.05, respectively) And no correlation between serum creatinine (P> 0.05). Conclusion The deficiency of 25 (OH) D3 may be related to the occurrence and development of type 2 diabetic nephropathy. The increase of chronic inflammation may be related to the deficiency of 25 (OH) D3.