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对沙土鼠(gerbil)进行单侧颈总动脉结扎,做成单侧脑缺血的动物模型,运用高效液相色谱电化学检测仪测定,研究额叶皮质区、尾状核区、海马区内神经递质多巴胺及5羟色胺在恢复过程中不同存活期内的含量变化,其中下降最显著的在海马组内,损伤侧DA下降到仅占对照侧的33%,P<0.01(第七天);在尾状核组内,5HT下降到仅占对照侧的38%,P<0.01(第七天),但额叶皮质组内二者变化不显著,为防治脑血管疾患提供了客观指标。
Unilateral carotid artery ligation was performed on gerbil to establish a model of unilateral cerebral ischemia. The contents of cortisol, caudate nucleus and hippocampus in the frontal lobe were measured by high performance liquid chromatography-electrochemical detector Changes of neurotransmitter dopamine and serotonin in different survival stages of the recovery process, the most significant decrease in the hippocampus group, damaging side DA decreased to only 33% of the control side, P <0.01 (seventh day) In the caudate nucleus, the 5HT decreased to only 38% of the control side, P <0.01 (seventh day), but the change in the frontal cortex group was insignificant, providing an objective indicator for the prevention and treatment of cerebrovascular diseases.