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盐酸丁卡因注射液含量测定方法以中和法最为常见,但各地使用溶剂不一,差异较大,其中中性乙醇、中性乙醇氯仿(1:1)结果偏低,中性氯仿稍偏高。实验表明,以中性氯仿乙醇(9:1)、中性苯乙醇(9:1)、中性乙醚乙醇(1:9)作溶媒,结果较理想。此外,实验还表明分光光度法、永停法测定本制剂含量,受仪器性能影响,准确度较差;银量法准确度较好,但受氯化钠等干扰难以应用。
The method of determination of tetracaine hydrochloride injection by neutralization method is the most common, but different solvents used in different places, large differences, including neutral ethanol, neutral ethanol chloroform (1: 1) results low, neutral chloroform slightly high. Experiments show that with neutral chloroform and ethanol (9: 1), neutral phenylethyl alcohol (9: 1), neutral ethyl ether alcohol (1: 9) as a solvent, the result is more satisfactory. In addition, the experiment also showed that spectrophotometry, the determination of the content of the formulation by the permanent stop method, the performance of the instrument, the accuracy is poor; silver method is better, but difficult to apply interference by sodium chloride.