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目的：探讨中华眼镜蛇毒 (naja naja atra venom,NNAV)对小鼠肉瘤 S180的抑制作用和血浆内皮素的影响。方法：通过体内实验，用不同剂量的 NNAV对荷肉瘤 S180小鼠进行治疗，观察其对小鼠肉瘤 S180的影响，并利用放射免疫测定法 (RIA)测定荷瘤小鼠血浆内皮素 (ET)含量。结果：经过小、中和大剂量（ 20μ g/kg, 40μ g/kg和 80μ g/kg） NNAV治疗后 ,其中大剂量组对小鼠肉瘤 S180有明显的抑瘤作用，抑瘤率为 49.25％，同时发现荷 S180肉瘤小鼠血浆内皮素水平明显高于正常对照组（ P
Objective: To investigate the inhibitory effect of naja naja atra venom (NNAV) on mouse sarcoma S180 and the effect of plasma endothelin. Methods: S180 mice bearing sarcoma were treated with different doses of NNAV in vivo, and their effects on mouse sarcoma S180 were observed. Plasma endothelin (ET) in tumor-bearing mice was measured by radioimmunoassay (RIA). content. RESULTS: After small, medium, and high doses (20, 40, and 80 μg/kg) of NNAV, the large-dose group had significant anti-tumor effect on mouse sarcoma S180, with a tumor inhibition rate of 49.25. %, At the same time, the plasma endothelin level in mice bearing sarcoma 180 was significantly higher than that in the normal control group (P