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随着肺动脉高压研究的不断深入,肺血管内皮细胞凋亡在肺动脉高压形成过程中的重要作用被逐步认识。多种疾病和环境因素导致肺血管内皮损伤、内皮细胞凋亡增加、功能障碍,从而促进肺动脉平滑肌细胞和成纤维细胞增殖、肺动脉重构和血栓形成;肺血管内皮细胞凋亡还诱导产生凋亡抵抗表型的内皮细胞过度增殖,形成丛样病变和肺血管闭塞,最终导致严重肺动脉高压。因而在肺动脉高压发生发展的不同时期,调控肺血管内皮细胞凋亡可能是预防和治疗肺动脉高压的一种新策略。
With the continuous research of pulmonary hypertension, the important role of pulmonary vascular endothelial cell apoptosis in the formation of pulmonary hypertension is gradually recognized. A variety of diseases and environmental factors lead to pulmonary vascular endothelial injury, endothelial cell apoptosis increased, dysfunction, thereby promoting pulmonary artery smooth muscle cells and fibroblasts proliferation, pulmonary artery remodeling and thrombosis; pulmonary vascular endothelial cell apoptosis also induced apoptosis Phenotypic endothelial cell proliferation over proliferation, the formation of cluster-like lesions and pulmonary vascular occlusion, eventually leading to severe pulmonary hypertension. Thus at different stages of the development of pulmonary hypertension, the regulation of apoptosis of pulmonary vascular endothelial cells may be a new strategy for the prevention and treatment of pulmonary hypertension.