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本文讨论苯雨咪唑(BZ)与哺乳类及BZ抗性和敏感蠕虫微管蛋白间相互作用的生物化学,探索这些药物选择毒性的各个方面,并探讨BZ抗性的机制。
This article discusses the biochemistry of the interaction between benzimidazole (BZ) and mammalian and BZ resistant and sensitive worm tubulin, explores various aspects of the toxicity of these drugs and explores the mechanisms of BZ resistance.