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失能性毒剂是一类新的军用毒剂。美国于50年代初开始研制,1962年正式装备代号为BZ的第一代失能性毒剂,1973年公开了它的化学结构,即二苯羟乙酸-3-喹咛环酯,属于中枢抗胆碱能类失能性毒剂。由于合成困难,价格昂贵,个体差异大,中毒效果较其它毒剂更加难以预测,美军认为BZ不是一个理想的毒剂。但是美军并没有放弃这个方向,而是继续在中枢抗胆碱能化合物中寻找更为理想的第二代失能性毒剂。第二代失能性毒剂以EA3834化合物为代表,据推测属于替代羟乙酸酯类。与BZ比较,它的穿透皮肤的性能有了明显改善。
Disabling agents are a new class of military agents. The United States started the development in the early 1950s. The first generation of incapacitated poison, codenamed BZ, was formally introduced in 1962. Its chemical structure was disclosed in 1973, ie, benzethonium dibenzophenone belongs to the central gallbladder Alkali type disability poison. Due to the difficulty of synthesis, the high cost and the large individual differences, the poisoning effect is more unpredictable than other agents. The U.S. military considers BZ not to be an ideal poison. However, the U.S. military did not abandon this direction. Instead, it continued to search for more ideal second-generation incapacitating agents in central anticholinergic compounds. The second generation of disabling agents, represented by EA3834 compounds, are presumably belonged to the alternative glycolates. Compared with BZ, it has significantly improved skin penetration performance.