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为研究中药冰糖对药物在体内药动学的影响 ,进而分析和探讨一些含冰糖成份的中药剂型中冰糖可能起的作用 ,该文采用分光光度法 ,测定并比较了家兔单独口服 (灌胃 )扑热息痛和合并冰糖口服(灌胃 )以后的体内血药浓度及一些药动学参数的变化。结果显示 ,合并使用冰糖使家兔体内血清扑热息痛的 Cmax比单独口服扑热息痛降低 3.5倍 ,ACU0→ 5.5降低了 2 .6倍。而 Ka、Ke值均降低 ,显示冰糖可延缓扑热息痛在体内的吸收及排泄
In order to study the influence of Chinese medicine rock sugar on the pharmacokinetics of the drug in vivo, and then to analyze and discuss the possible role of some crystal sugars containing Chinese rock sugar in the Chinese medicinal formula, the authors used the spectrophotometric method to determine and compare the rabbit oral administration alone (gastric administration). ) Changes in blood plasma concentrations and some pharmacokinetic parameters after paracetamol and oral administration of globose (intragastric administration). The results showed that the combined use of rock sugar reduced the Cmax of serum paracetamol in rabbits by 3.5-fold compared with oral acetaminophen alone, and ACU0→5.5 decreased by 2.6%. The decrease of Ka and Ke values showed that rock sugar can delay the absorption and excretion of paracetamol in the body.